Mineo Takei Selected Research

specific substance maruyama (Z-100)

3/2015	Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, promotes TNF-α production via nucleotide-binding oligomerization domain containing 2 (Nod2)-dependent NF-κB activation in RAW264.7 cells.
1/2014	Z-100, an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B, prevents spontaneous lymphatic metastasis of B16-BL6 melanoma.
9/2004	Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.
1/2004	Z-100, an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, augments anti-tumor activities of X-ray irradiation against B16 melanoma in association with the improvement of type 1T cell responses.
9/2003	Antimetastatic effect of an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, Z-100, through the production of interleukin-12.

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Mineo Takei Research Topics

Disease

8	Neoplasms (Cancer) 01/2018 - 09/2003
6	Stress Urinary Incontinence 01/2021 - 03/2005
5	Pancreatic Neoplasms (Pancreatic Cancer) 10/2011 - 04/2008
4	Overactive Urinary Bladder (Overactive Bladder) 01/2021 - 05/2005
4	Dyspepsia (Indigestion) 02/2014 - 03/2011
3	Urinary Incontinence 01/2021 - 01/2009
3	Melanoma (Melanoma, Malignant) 01/2014 - 09/2003
2	Interstitial Cystitis (Interstitial Cystitis, Chronic) 01/2021 - 12/2007
2	Weight Loss (Weight Reduction) 01/2020 - 01/2018
2	Anorexia 01/2020 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2014 - 09/2003
2	Taste Disorders (Taste Disorder) 01/2012 - 01/2006
2	Pain (Aches) 10/2010 - 01/2010
2	Adenocarcinoma 01/2010 - 04/2008
2	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 11/2009 - 11/2004
2	Lower Urinary Tract Symptoms 01/2008 - 01/2006
1	Prostatitis 04/2022
1	Stomach Neoplasms (Stomach Cancer) 01/2020
1	Body Weight (Weight, Body) 01/2018
1	Diabetes Mellitus 01/2018
1	Cachexia 09/2017
1	Lymphatic Metastasis 01/2014
1	Stomach Ulcer (Gastric Ulcer) 01/2012
1	Carcinogenesis 10/2011
1	Hypoxia (Hypoxemia) 10/2011
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/2011
1	Cystocele 03/2011
1	Cancer Pain 01/2010
1	Ageusia (Hypogeusia) 11/2009
1	Neurogenic Urinary Bladder (Bladder, Neurogenic) 11/2009
1	Nocturia 01/2009
1	Dysgeusia (Parageusia) 01/2006
1	Urinary Tract Infections (Urinary Tract Infection) 11/2004
1	Hematologic Diseases (Blood Diseases) 11/2004

Drug/Important Bio-Agent (IBA)

5	specific substance maruyama (Z-100)IBA 03/2015 - 09/2003
5	Z-360IBA 10/2011 - 04/2008
4	Z 338IBA 02/2014 - 03/2011
4	Pharmaceutical PreparationsIBA 01/2012 - 01/2010
4	Gemcitabine FDA Link 10/2011 - 04/2008
4	Cholecystokinin B ReceptorIBA 10/2011 - 04/2008
3	Hormones (Hormone)IBA 01/2020 - 09/2017
3	GhrelinIBA 01/2020 - 09/2017
3	Ghrelin ReceptorsIBA 01/2020 - 09/2017
3	polaprezinc (Z 103)IBA 01/2012 - 01/2006
3	Cholecystokinin (Pancreozymin)IBA 01/2010 - 04/2008
2	Z-505 hydrochlorideIBA 01/2018 - 09/2017
2	ZincIBA 01/2012 - 01/2006
2	GastrinsIBA 10/2011 - 04/2008
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2011 - 01/2010
2	Analgesics (Analgesic Drugs)IBA 10/2010 - 01/2010
2	CytokinesIBA 01/2004 - 09/2003
1	NickelIBA 04/2022
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2021
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2021
1	SolutionsIBA 01/2021
1	Botulinum Toxins (Botulinum Toxin)IBA 01/2021
1	TAS-303IBA 01/2021
1	Cisplatin (Platino)FDA LinkGeneric 01/2018
1	Fluorouracil (Carac)FDA LinkGeneric 01/2018
1	Interleukin-6 (Interleukin 6)IBA 09/2017
1	Insulin-Like PeptidesIBA 09/2017
1	CorticosteroneIBA 09/2017
1	Insulin (Novolin)FDA Link 09/2017
1	TabletsIBA 02/2014
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	Granzymes (Granzyme)IBA 01/2014
1	Cholinergic Antagonists (Anticholinergics)IBA 05/2013
1	Type A Botulinum Toxins (Botox)FDA Link 05/2013
1	CarnosineIBA 01/2012
1	Mesalamine (Mesalazine)FDA LinkGeneric 08/2011
1	ThiazolesIBA 03/2011
1	Tyrosine (L-Tyrosine)FDA Link 10/2010
1	Interleukin-1 (Interleukin 1)IBA 10/2010
1	Sincalide FDA Link 10/2010
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2010
1	DevazepideIBA 10/2010
1	Opioid Analgesics (Opioids)IBA 10/2010
1	Ephrin-B1 (Ephrin B1)IBA 10/2010
1	Cholecystokinin A ReceptorIBA 01/2010
1	Morphine (MS Contin)FDA LinkGeneric 01/2010
1	Formaldehyde (Formol)FDA Link 01/2010
1	CalciumIBA 04/2008
1	Benzoates (Benzoate)IBA 04/2008
1	Tolterodine Tartrate (Detrol)FDA Link 05/2005
1	oxybutynin (Tavor)FDA LinkGeneric 05/2005

Therapy/Procedure

5	Therapeutics 01/2018 - 01/2004
4	Suburethral Slings (Tension-Free Vaginal Tape) 01/2021 - 03/2005
4	Transurethral Resection of Prostate (TURP) 01/2009 - 11/2004
2	Artificial Urinary Sphincter 11/2009 - 01/2009
1	Intravesical Administration 01/2021
1	Gastrectomy 01/2020
1	Drug Therapy (Chemotherapy) 01/2018
1	Reoperation 01/2018
1	Immunotherapy 03/2015
1	Pessaries 03/2011
1	Intraperitoneal Injections 10/2010
1	Oral Administration 01/2010
1	Prostatectomy (Retropubic Prostatectomy) 11/2009
1	Indwelling Catheters (Indwelling Catheter) 11/2004
1	Blood Transfusion (Blood Transfusions) 11/2004